AP C5 |
| Catalog No.GC50527 |
AP C5는 pIC50이 7.2인 구아노신 3',5'-사이클릭 모노포스페이트(cGMP) 의존성 단백질 키나아제 II(cGKII)를 선택적으로 억제하여 설사 질환 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2234272-10-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.
Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID:29653944
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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