Bis-PEG2-acid |
| رقم الكتالوجGC60086 |
Bis-PEG2-acid عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تخليق PROTACs
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Cas No.: 19364-66-0
Sample solution is provided at 25 µL, 10mM.
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Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.
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