Cathepsin C-IN-5 |
| رقم الكتالوجGC65998 |
Cathepsin C-IN-5 (المركب SF38) هو مثبط قوي ، انتقائي وفعال عن طريق الفم Cathepsin C مع IC50s 59.9 نانومتر ، 4.26 μ ؛ M ،> 5 μ ؛ M ،> 5 μ ؛ M ،> 5 μ ؛ M لـ Cat C ، Cat L ، Cat S ، Cat B ، Cat K ، على التوالي. يثبط Cathepsin C-IN-5 نشاط Cat C في نخاع العظام والدم. يقلل Cathepsin C-IN-5 من تنشيط NSPs (بروتينات سيرين العدلات). يُظهر Cathepsin C-IN-5 نشاطًا مضادًا للالتهابات.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2825567-97-1
Sample solution is provided at 25 µL, 10mM.
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Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity[1].
Cathepsin C-IN-5 (compound SF38) shows inhibition in THP-1 and U937 cells with IC50s of 115.4, 70.2 nM, respectively[1].
Cathepsin C-IN-5 (1500 mg/kg) shows no significant weight loss or toxic reaction within 7 days after the administration in ICR mice[1].
Cathepsin C-IN-5 (10 mg/kg for p.o.; 2 mg/kg for i.v.) shows good bioavailability with F=42.07%[1].
Cathepsin C-IN-5 (2, 10, 50 mg/kg; p.o.) shows effective antiinflammatory activity and potential protective effect in an animal model of ALI[1].
| Animal Model: | C57BL/6 male mice (acute lung injury (ALI) mice model)[1] |
| Dosage: | 2, 10, 50 mg/kg (one hour after administration, received LPS (20 mg/kg)) |
| Administration: | P.o. |
| Result: | Decreased the levels of proinflammatory cytokines (TNF-a, IL-6, and GM-CSF) and increased the the concentration of the anti-inflammatory cytokine (IL-10) in a dose-dependent manner. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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