Cathepsin C-IN-5 |
| カタログ番号GC65998 |
カテプシン C-IN-5 (化合物 SF38) は、59.9 nM の IC50、4.26 μM、>5 μM、>5 μM、>5 &8888 の強力で選択的な経口活性カテプシン C 阻害剤です。それぞれ猫 C、猫 L、猫 S、猫 B、猫 K。カテプシン C-IN-5 は、骨髄および血液中の Cat C 活性を阻害します。カテプシン C-IN-5 は、NSP (好中球セリンプロテアーゼ) の活性化を低下させます。カテプシン C-IN-5 は、抗炎症活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2825567-97-1
Sample solution is provided at 25 µL, 10mM.
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Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 µM, >5 µM, >5 µM, >5 µM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity[1].
Cathepsin C-IN-5 (compound SF38) shows inhibition in THP-1 and U937 cells with IC50s of 115.4, 70.2 nM, respectively[1].
Cathepsin C-IN-5 (1500 mg/kg) shows no significant weight loss or toxic reaction within 7 days after the administration in ICR mice[1].
Cathepsin C-IN-5 (10 mg/kg for p.o.; 2 mg/kg for i.v.) shows good bioavailability with F=42.07%[1].
Cathepsin C-IN-5 (2, 10, 50 mg/kg; p.o.) shows effective antiinflammatory activity and potential protective effect in an animal model of ALI[1].
| Animal Model: | C57BL/6 male mice (acute lung injury (ALI) mice model)[1] |
| Dosage: | 2, 10, 50 mg/kg (one hour after administration, received LPS (20 mg/kg)) |
| Administration: | P.o. |
| Result: | Decreased the levels of proinflammatory cytokines (TNF-a, IL-6, and GM-CSF) and increased the the concentration of the anti-inflammatory cytokine (IL-10) in a dose-dependent manner. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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