CB1151 |
| رقم الكتالوجGC39133 |
CB1151 هو نظير 20-epi من 1،25 ثنائي هيدروكسي فيتامين D3 (VD) مع تأثيرات قوية مضادة للورمCB1151 يمنع نمو خلية MCF-7 بقيمة IC50 تبلغ 0.82 نانومتر
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Cas No.: 182369-28-4
Sample solution is provided at 25 µL, 10mM.
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CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1].
[1]. MØrk Hansen C, et al. The potent anti-proliferative effect of 20-epi analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity.Int J Cancer. 1996 Sep 4;67(5):739-42. [2]. Nayeri S, et al. High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation.J Cell Biochem. 1996 Sep 1;62(3):325-33.
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