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CB1151

Katalog-Nr.GC39133

CB1151 ist ein 20-epi-Analogon von 1,25-Dihydroxyvitamin D3 (VD) mit starker Antitumorwirkung. CB1151 hemmt das Wachstum von MCF-7-Zellen mit einem IC50-Wert von 0,82 nM.

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CB1151 Chemische Struktur

Cas No.: 182369-28-4

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1].

[1]. MØrk Hansen C, et al. The potent anti-proliferative effect of 20-epi analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity.Int J Cancer. 1996 Sep 4;67(5):739-42. [2]. Nayeri S, et al. High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation.J Cell Biochem. 1996 Sep 1;62(3):325-33.

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