CH6953755 |
| رقم الكتالوجGC39557 |
CH6953755 هو مثبط فعال وانتقائي وفعال عن طريق الفم YES1 كيناز (عضو في عائلة SRC) مع IC50 يبلغ 1.8 نانومترCH6953755 يثبط YES1 كيناز ، مما يؤدي إلى نشاط مضاد للأورام ضد السرطانات المضخمة لـ YES1 في المختبر وفي الجسم الحي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055918-71-1
Sample solution is provided at 25 µL, 10mM.
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CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo[1].
[1]. Hamanaka N, et al. YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. Cancer Res. 2019 Nov 15;79(22):5734-5745.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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