CH6953755 |
| Catalog No.GC39557 |
CH6953755 es un inhibidor potente, activo por vÍa oral y selectivo de la cinasa YES1 (un miembro de la familia SRC) con una IC50 de 1,8 nM. CH6953755 inhibe la quinasa YES1, lo que lleva a la actividad antitumoral contra los cÁnceres amplificados por el gen YES1 in vitro e in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055918-71-1
Sample solution is provided at 25 µL, 10mM.
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CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo[1].
[1]. Hamanaka N, et al. YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification. Cancer Res. 2019 Nov 15;79(22):5734-5745.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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