Corylin |
رقم الكتالوجGC32956
One-Click Copy Product Info
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Corylin هو مركب حيوي رئيسي معزول عن Psoralea corylifolia L ؛ مركب مضاد حيوي أو مضاد للسرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53947-92-5
Sample solution is provided at 25 µL, 10mM.
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Corylin is a phenolic compound isolated from the Psoralea corylifolia L, with anti-inflammatory and immunosuppressive properties [1]. Corylin activates BAT and Beige adipocytes through SIRT1 and β3-AR regulation, exerting anti-obesity effect[2]. Corylin has been widely used to prolong the life span of aged mice under metabolic stress, improve physiological function, reduce metabolic stress and maintain tissue function[3].
In vitro, Corylin treatment for 24 hours significantly inhibited the proliferation of MCF-7 cells and MDA-MB-231 cells with IC50 values of 10.58µM and 13.59µM, respectively[4]. Treatment of RAW264.7 cells with 10µM Corylin for 24h inhibited cell viability and migration[5]. Pretreatment of BV2 cells with 10µM Corylin for 1 hour attenuated lipopolysaccharide (LPS) -induced inflammatory response, reduced TNF-α and IL-6 production, and inhibited MAPK phosphorylation[6].
In vivo, Corylin treatment via oral administration at a dose of 50mg/kg/day for 15 weeks reduced oxidative stress, VCAM-1 and NOX4 Expression, and atherosclerotic plaques in the thoracic aorta of cholesterol diet-treated mice[7]. Intraperitoneal injection of a single dose of Corylin (20mg/kg) for 12 hours significantly alleviated LPS-induced cardiac dysfunction and reduced inflammation in mice[8].
References:
[1] Qin Z, Li S, Yao Z, et al. Metabolic profiling of corylin in vivo and in vitro[J]. Journal of pharmaceutical and biomedical analysis, 2018, 155: 157-168.
[2] Chen C C, Kuo C H, Leu Y L, et al. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation[J]. Pharmacological Research, 2021, 164: 105291.
[3] Wang T H, Tseng W C, Leu Y L, et al. The flavonoid corylin exhibits lifespan extension properties in mouse[J]. Nature communications, 2022, 13(1): 1238.
[4] Liu S, Wang L, Zhang R. Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target[J]. Libyan Journal of Medicine, 2021, 16(1): 1883224.
[5] Liu N, Yang Z, Yanzhang R, et al. Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway[J]. Scientific Reports, 2025, 15(1): 40724.
[6] Huang M Y, Tu C E, Wang S C, et al. Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia[J]. BMC complementary and alternative medicine, 2018, 18(1): 221.
[7] Chen C C, Li H Y, Leu Y L, et al. Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-deficient mice[J]. Antioxidants, 2020, 9(4): 275.
[8] Li C, Hou D, Huang Y, et al. Corylin alleviated sepsis-associated cardiac dysfunction via attenuating inflammation through downregulation of microRNA-214-5p[J]. Toxicology Research, 2024, 13(3): tfae081.
| Cell experiment [1]: | |
Cell lines | MCF-7 cells |
Preparation Method | MCF-7 cells were cultured in DMEM medium supplemented with 10% fetal bovine serum (FBS) and antibiotics (penicillin 100U/ml, streptomycin 0.1mg/ml). Cells were seeded in 6-well plates and then treated with different concentrations of Corylin (0, 2.5, 5, 10, 15, 20μM) for 24h to analyze cell viability. |
Reaction Conditions | 0, 2.5, 5, 10, 15, 20μM; 24h |
Applications | Corylin treatment decreased the cell viability of MCF-7 cells in a dose-dependent manner. |
| Animal experiment [2]: | |
Animal models | Male ApoE-deficient C57/BL6 mice |
Preparation Method | Male ApoE-deficient C57/BL6 mice (8 weeks of age) were maintained in a standard environment. Mice were randomly divided into the following three groups: group I (control group) were fed standard diet (n=12); group II (cholesterol diet group) was fed a high cholesterol diet (0.15% cholesterol) for 15 weeks (n=12); in the third group (cholesterol diet+Corylin, prevention group) mice were fed a high cholesterol diet and orally administered Corylin (50mg/kg/day) for 15 weeks (n=12). After 15 weeks, mice were euthanized with sodium pentobarbital (120mg/kg; i.p.), and the thoracic aorta was gently removed for analysis. |
Dosage form | 50mg/kg/day for 15 weeks; p.o. |
Applications | Corylin reduced oxidative stress, VCAM-1 and NOX4 expression, and atherosclerotic plaques in the thoracic aorta of cholesterol diet-treated mice. |
References: | |
| Cas No. | 53947-92-5 | SDF | |
| Canonical SMILES | O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2)=COC4=CC(O)=CC=C14 | ||
| Formula | C20H16O4 | M.Wt | 320.34 |
| الذوبان | DMSO : ≥ 100 mg/mL (312.17 mM);Water : < 0.1 mg/mL (insoluble) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1217 mL | 15.6084 mL | 31.2168 mL |
| 5 mM | 624.3 μL | 3.1217 mL | 6.2434 mL |
| 10 mM | 312.2 μL | 1.5608 mL | 3.1217 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)