Cyclic AMP (Synonyms: Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670) |
| رقم الكتالوجGC19626 |
Cyclic AMP (Cyclic Adenosine monophosphate) ، أحد مشتقات الأدينوزين ثلاثي الفوسفات ، هو جزيء إشارات داخل الخلايا مسؤول عن توجيه الاستجابات الخلوية للإشارات خارج الخلية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60-92-4
Sample solution is provided at 25 µL, 10mM.
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Cyclic AMP (cAMP) is a derivative of adenosine triphosphate and is the first identified second messenger that transmits signals from receptors to downstream pathways[1]. As an important intracellular signaling molecule, cyclic AMP participates in many biological processes, such as metabolic regulation, protein kinase activation, gene transcription, etc.[2, 3]. Cyclic AMP is produced from ATP by several adenylate cyclases and anchored in various locations inside the cell. These enzymes are regulated by G protein-coupled receptors [4]. Cyclic AMP is broken down into adenosine monophosphate (AMP) by phosphodiesterases [5]. Cyclic AMP is a hydrophilic small molecule that contains a phosphate group, has high polarity, and can form hydrogen bonds with water molecules [6].
References:
[1] Muthal A P, Kulkarni R, Kumar D, et al. Cyclic adenosine monophosphate: Recent and future perspectives on various diseases[J]. Journal of Applied Pharmaceutical Science, 2022, 12(3): 001-015.
[2] Rutter G A, da Silva Xavier G, Leclerc I. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis[J]. Biochemical Journal, 2003, 375(1): 1-16.
[3] De Cesare D, Sassone-Corsi P. Transcriptional regulation by cyclic AMP-responsive factors[J]. 2000.
[4] Kuhn M. Molecular physiology of membrane guanylyl cyclase receptors[J]. Physiological reviews, 2016.
[5] Pyne N J, Furman B L. Cyclic nucleotide phosphodiesterases in pancreatic islets[J]. Diabetologia, 2003, 46: 1179-1189.
[6] Kato Y, Conn M M, Rebek J J. Water-soluble receptors for cyclic-AMP and their use for evaluating phosphate-guanidinium interactions[J]. Journal of the American Chemical Society, 1994, 116(8): 3279-3284.
| Cas No. | 60-92-4 | SDF | |
| المرادفات | Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670 | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@@]4([H])[C@@]1([H])OP(OC4)(O)=O | ||
| Formula | C10H12N5O6P | M.Wt | 329.21 |
| الذوبان | insoluble in DMSO; insoluble in EtOH; 11mg/mL in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0376 mL | 15.1879 mL | 30.3757 mL |
| 5 mM | 0.6075 mL | 3.0376 mL | 6.0751 mL |
| 10 mM | 0.3038 mL | 1.5188 mL | 3.0376 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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