Cyclic AMP (Synonyms: Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670) |
カタログ番号GC19626
One-Click Copy Product Info
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環状AMP(cAMP)（Cyclic AMP）は、アデノシン三リン酸の誘導体であり、シグナルを受容体から下流経路に転移させる、最初に確認された二次メッセンジャーである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60-92-4
Sample solution is provided at 25 µL, 10mM.
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環状AMP(cAMP)（Cyclic AMP）は、アデノシン三リン酸の誘導体であり、シグナルを受容体から下流経路に転移させる、最初に確認された二次メッセンジャーである[1]。環状AMPは重要な細胞内シグナル分子として、代謝制御、タンパク質キナーゼ活性化、遺伝子転写など様々な生物学的プロセスに関与している[2, 3]。環状AMPは幾つかのアデニル酸シクラーゼを通じてATPから生成され、細胞内の様々なところで固定されている。これらの酵素は、Gタンパク質共役受容体に制御される[4]。環状AMPはホスホジエステラーゼによってアデノシン一リン酸に分解される[5]。環状AMPは親水性の小分子であり、リン酸グループを持ち、高い極性と持ち、水分子とともに水素結合を形成できる[6]。
References:
[1] Muthal A P, Kulkarni R, Kumar D, et al. Cyclic adenosine monophosphate: Recent and future perspectives on various diseases[J]. Journal of Applied Pharmaceutical Science, 2022, 12(3): 001-015.
[2] Rutter G A, da Silva Xavier G, Leclerc I. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis[J]. Biochemical Journal, 2003, 375(1): 1-16.
[3] De Cesare D, Sassone-Corsi P. Transcriptional regulation by cyclic AMP-responsive factors[J]. 2000.
[4] Kuhn M. Molecular physiology of membrane guanylyl cyclase receptors[J]. Physiological reviews, 2016.
[5] Pyne N J, Furman B L. Cyclic nucleotide phosphodiesterases in pancreatic islets[J]. Diabetologia, 2003, 46: 1179-1189.
[6] Kato Y, Conn M M, Rebek J J. Water-soluble receptors for cyclic-AMP and their use for evaluating phosphate-guanidinium interactions[J]. Journal of the American Chemical Society, 1994, 116(8): 3279-3284.
| Cas No. | 60-92-4 | SDF | |
| 同義語 | Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670 | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@@]4([H])[C@@]1([H])OP(OC4)(O)=O | ||
| Formula | C10H12N5O6P | M.Wt | 329.21 |
| 溶解度 | insoluble in DMSO; insoluble in EtOH; 11mg/mL in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0376 mL | 15.1879 mL | 30.3757 mL |
| 5 mM | 607.5 μL | 3.0376 mL | 6.0751 mL |
| 10 mM | 303.8 μL | 1.5188 mL | 3.0376 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)