Cyclic AMP (Synonyms: Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670) |
Catalog No.GC19626
One-Click Copy Product Info
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Cyclic AMP(cAMP)는 아데노신 삼인산의 유도체로 수용체에서 하류 경로로 신호를 전달하는 최초의 확인된 두 번째 메신저이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60-92-4
Sample solution is provided at 25 µL, 10mM.
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Cyclic AMP(cAMP)는 아데노신 삼인산의 유도체로 수용체에서 하류 경로로 신호를 전달하는 최초의 확인된 두 번째 메신저이다. 중요한 세포 내 신호 분자로서 Cyclic AMP는 대사 조절, 단백질 키나제 활성화, 유전자 전사 등 많은 생물학적 과정에 참여한다[2, 3]. Cyclic AMP는 여러 아데닐레이트 사이클라제에 의해 ATP에서 생성되고 세포 내 다양한 위치에 고정된다. 이러한 효소는 G 단백질 결합 수용체에 의해 조절된다[4]. Cyclic AMP는 포스포디에스터라제에 의해 아데노신 단인산(AMP)으로 분해된다[5]. Cyclic AMP는 인산기 그룹을 포함하고 높은 극성을 가지고 물 분자와 수소 결합을 형성할 수 있는 친수성 소분자이다[6].
References:
[1] Muthal A P, Kulkarni R, Kumar D, et al. Cyclic adenosine monophosphate: Recent and future perspectives on various diseases[J]. Journal of Applied Pharmaceutical Science, 2022, 12(3): 001-015.
[2] Rutter G A, da Silva Xavier G, Leclerc I. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis[J]. Biochemical Journal, 2003, 375(1): 1-16.
[3] De Cesare D, Sassone-Corsi P. Transcriptional regulation by cyclic AMP-responsive factors[J]. 2000.
[4] Kuhn M. Molecular physiology of membrane guanylyl cyclase receptors[J]. Physiological reviews, 2016.
[5] Pyne N J, Furman B L. Cyclic nucleotide phosphodiesterases in pancreatic islets[J]. Diabetologia, 2003, 46: 1179-1189.
[6] Kato Y, Conn M M, Rebek J J. Water-soluble receptors for cyclic-AMP and their use for evaluating phosphate-guanidinium interactions[J]. Journal of the American Chemical Society, 1994, 116(8): 3279-3284.
| Cas No. | 60-92-4 | SDF | |
| Synonyms | Adenosine 3',5'-cyclic monophosphate, cAMP, Cyclic adenosine monophosphate, NSC 94017, NSC 143670 | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@@]4([H])[C@@]1([H])OP(OC4)(O)=O | ||
| Formula | C10H12N5O6P | M.Wt | 329.21 |
| Solubility | insoluble in DMSO; insoluble in EtOH; 11mg/mL in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0376 mL | 15.1879 mL | 30.3757 mL |
| 5 mM | 607.5 μL | 3.0376 mL | 6.0751 mL |
| 10 mM | 303.8 μL | 1.5188 mL | 3.0376 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)