Doxapram |
| رقم الكتالوجGC16537 |
Doxapram يثبط TASK-1 ، TASK-3 ، TASK-1 / TASK-3 وظيفة القناة غير المتجانسة مع EC50 من 410 نانومتر ، 37 ميكرومتر ، 9 ميكرومتر ، على التوالي
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Cas No.: 309-29-5
Sample solution is provided at 25 µL, 10mM.
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Doxapram is a strong, dose-dependent respiratory stimulant in mammals. The oral LD50 in rats is 211mg/kg [1].
After Doxapram treatment, it has been noted a pressor response action through stimulation of the central nervous system (CNS). In addition, Doxapram has shown not only the central sensitization but also the prtipheral sensitization to hypercarbia in both animal and human studies. Furthermore, Doxapram has been reported to stimulate the carotid body in a dose-dependent fashion and have an additive but not synergistic effect on the carotid body response to hupercapnia. Apart from these, Doxapram has also shown the potent, direct and inhibitory effects on cloned TASK-1 and TASK-3 channels with the EC50 values of 410nM, 37nM and 9nM for TASK-1, TASK-3 and TASK-1/TASK-3, respectively. Doxapram has been revealed to augment neuromuscular transmission in a dose-related manner above a threshold concentration of 50μM [1].
References:
[1] Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rev. 2006 Fall-Winter;12(3-4):236-49.
| Cas No. | 309-29-5 | SDF | |
| Chemical Name | 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one | ||
| Canonical SMILES | CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4 | ||
| Formula | C24H30N2O2 | M.Wt | 378.51 |
| الذوبان | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6419 mL | 13.2097 mL | 26.4194 mL |
| 5 mM | 528.4 μL | 2.6419 mL | 5.2839 mL |
| 10 mM | 264.2 μL | 1.321 mL | 2.6419 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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