Dynorphin A (trifluoroacetate salt) (Synonyms: Dynorphin A (1-17)) |
رقم الكتالوجGC52500 |
An endogenous opioid receptor agonist
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Dynorphin A is a heptadecapeptide released from the cleavage of prodynorphin and found widely distributed in the central nervous system, where it is implicated in antinociceptive functions.1,2,3 It acts as an opioid receptor agonist with nanomolar binding affinity to the three major isotypes κ, µ, and δ (Kis = 0.5-1 nM) and has also been shown to activate human ORL1, a novel opioid receptor-like receptor (Ki = 386 nM).4
1.Berman, Y., Juliano, L., and Devi, L.A.Specificity of the dynorphin-processing endoprotease: Comparison with prohormone convertasesJ. Neurochem.72(5)2120-2196(1999) 2.Janecka, A., Fichna, J., and Janecki, T.Opioid receptors and their ligandsCurr. Top. Med. Chem.4(1)1-17(2004) 3.Dhawan, B.N., Cesselin, F., Raghubir, R., et al.International Union of Pharmacology. XII. Classification of opioid receptorsPharmacol. Rev.48(4)567-592(1996) 4.Zhang, S., Tong, Y., Tian, M., et al.Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene familyJ. Pharmacol. Exp. Ther.286(1)136-141(1998)
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(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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