EZM0414 |
| رقم الكتالوجGC64900 |
EZM0414 هو مثبط قوي ، انتقائي ، متاح حيويًا عن طريق الفم لـ SETD2 (IC50 = 18 نانومتر في اختبار الكيمياء الحيوية SETD2 ؛ IC50 = 34 نانومتر في الفحص الخلوي)يمكن استخدام EZM0414 للبحث عن الورم النقوي المتعدد الانتكاس أو المقاوم للحرارة وسرطان الغدد الليمفاوية B-cell الكبيرة المنتشرة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2411748-50-8
Sample solution is provided at 25 µL, 10mM.
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EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 (IC50=18 nM in SETD2 biochemical assay; IC50=34 nM in cellular assay). EZM0414 can be used for the research of relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma[1].
[1]. Jennifer Totman, et al. Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-cell Lymphoma.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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