Fezolinetant (ESN-364) |
| رقم الكتالوجGC30104 |
Fezolinetant (ESN-364) هو مضاد لمستقبلات Neurokinin 3 (NK3R) ، ويستخدم لعلاج الهبات الساخنة بعد انقطاع الطمث.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1629229-37-3
Sample solution is provided at 25 µL, 10mM.
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Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Fezolinetant (ESN364, 1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovarectomized ewe. ESN364 represses the pulse pattern of LH in all treated animals. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. ESN364 (10, 25, 50 mg/kg, orally) also blocks the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys[1].
[1]. Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.
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