Garcinoic Acid (Synonyms: δ-Garcinoic Acid, δ-trans-Tocotrienoloic Acid) |
| رقم الكتالوجGC46150 |
حمض الجارسينويك هو نظير فيتامين هـ المستخرج من بذور غارسينيا كولايُظهر حمض الجارسينويك تأثيرًا مضادًا للتكاثر بشكل ملحوظ على الخلايا السرطانية للورم الدبقي C6
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Cas No.: 91893-83-3
Sample solution is provided at 25 µL, 10mM.
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Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora.1 It inhibits IL-1β-induced microsomal prostaglandin E2 synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM.2 It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM.3
|1. Monache, F.D., Marta, M., Mac-Quhae, M.M., et al. Two new tocotrienoloic acids from the fruits of Clusia grandiflora Splith. Gazz. Chim. Ital. 114(3-4), 135-137 (1984).|2. Alsabil, K., Suor-Cherer, S., Koeberle, A., et al. Semisynthetic and natural garcinoic acid isoforms as new mPGES-1 inhibitors. Planta Med. 82(11-12), 1110-1116 (2016).|3. Terashima, K., Takaya, Y., and Niwa, M. Powerful antioxidative agents based on garcinoic acid from Garcinia kola. Bioorg. Med. Chem. 10(5), 1619-1625 (2002).
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