Duocarmycin |
| رقم الكتالوجGC35907 |
دوكارمايسين ، ألكيلاتور ذو أخدود ثانوي للحمض النووي ، هو دواء متقارن من مادة سامة (ADCs). يعتمد Duocarmycin على هيكل الإندول المنحني المميز و spirocyclopropylcyclohexadienone electrophile لعمل نشاط مضاد للسرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1116745-06-2
Sample solution is provided at 25 µL, 10mM.
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Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug-antibody conjugates (ADCs) [1].
[1]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.
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