Duocarmycin |
| カタログ番号GC35907 |
デュオカルマイシン、DNA マイナー グルーブ アルキル化剤は、抗体薬物複合体 (ADC) 毒素です。デュオカルマイシンは、その特徴的な湾曲したインドール構造とスピロシクロプロピルシクロヘキサジエノン求電子剤に基づいており、抗がん作用を発揮します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1116745-06-2
Sample solution is provided at 25 µL, 10mM.
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Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug-antibody conjugates (ADCs) [1].
[1]. Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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