DW14800 |
| رقم الكتالوجGC35914 |
DW14800 هو مثبط بروتين أرجينين ميثيل ترانسفيراز 5 (PRMT5) ، مع IC 50 من 17 نانومترDW14800 يقلل من مستويات H4R3me2s ويعزز نسخ HNF4α ، لكنه لا يغير تعبير PRMT5نشاط مضاد للسرطان
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Cas No.: 2243709-60-4
Sample solution is provided at 25 µL, 10mM.
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DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1]. PRMT5[1]
[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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