DW14800 |
| Catalog No.GC35914 |
DW14800 es un inhibidor de la proteÍna arginina metiltransferasa 5 (PRMT5), con una IC50 de 17 nM. DW14800 reduce los niveles de H4R3me2s y mejora la transcripciÓn de HNF4α, pero no altera la expresiÓn de PRMT5. Actividad anticancerÍgena.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2243709-60-4
Sample solution is provided at 25 µL, 10mM.
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DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1]. PRMT5[1]
[1]. Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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