Isoviolanthin |
| رقم الكتالوجGC36349 |
يمكن أن يمنع Isoviolanthin ، وهو جليكوسيد الفلافونويد ، بشكل ملحوظ الهجرة والغزو بوساطة TGF-β1 عن طريق إلغاء تنشيط الانتقال الظهاري المتوسط (EMT) عبر مسارات TGF-β / Smad و PI3K / Akt / mTOR في خلايا سرطان الكبدلا يُظهر Isoviolanthin أي تأثيرات سامة للخلايا على خلايا الكبد LO2 الطبيعية
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Cas No.: 40788-84-9
Sample solution is provided at 25 µL, 10mM.
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Isoviolanthin is a flavonoid glycoside extracted from the leaves of Dendrobium officinale. Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells but exhibits no cytotoxic effects on normal live cells, and has potential as a therapeutic agent for the treatment of advanced-stage metastatic HCC[1].
[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial?Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).
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