Isoviolanthin |
| Catalog No.GC36349 |
La isoviolantina, un glucÓsido flavonoide, podrÍa inhibir notablemente la migraciÓn y la invasiÓn mediadas por TGF-β1 al desactivar la transiciÓn epitelial-mesenquimatosa (EMT) a través de las vÍas TGF-β/Smad y PI3K/Akt/mTOR en células de CHC. La isoviolantina no presenta efectos citotÓxicos en las células LO2 hepÁticas normales.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40788-84-9
Sample solution is provided at 25 µL, 10mM.
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Isoviolanthin is a flavonoid glycoside extracted from the leaves of Dendrobium officinale. Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells but exhibits no cytotoxic effects on normal live cells, and has potential as a therapeutic agent for the treatment of advanced-stage metastatic HCC[1].
[1]. Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial?Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19(6).
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