Kushenol A |
| رقم الكتالوجGC36402 |
يتم عزل Kushenol A (Leachianone E) من جذر Sophora flavescentKushenol A هو مثبط غير تنافسي لتيروزيناز لمنع تحويل L-tyrosine إلى L-DOPA ، ويظهر IC50 و Kivalues ==1.1 ميكرومتر و 0.4 ميكرومتر ، على التواليKushenol A هو أحد مضادات الأكسدة الفلافونويدية ، وله تأثيرات مثبطة على alpha-glucosidase (IC50: 45 ميكرومتر ؛ Ki: 6.8 ميكرومتر) و β-amylaseتم تأكيد Kushenol A كمثبطات محتملة للإنزيمات التي تستهدفها مستحضرات التجميل لتبييض البشرة والشيخوخة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 99217-63-7
Sample solution is provided at 25 µL, 10mM.
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Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.
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