Kushenol A |
| Catalog No.GC36402 |
Kushenol A(Leachianone E)는 Sophora flavescent의 뿌리에서 분리됩니다. Kushenol A는 L-tyrosine이 L-DOPA로 전환되는 것을 차단하는 non-competitive tyrosinase inhibitor로 IC50과 Kivalue가 각각 1.1μM, 0.4μM이다. Kushenol A는 플라보노이드 항산화제로 alpha-glucosidase(IC50: 45μM, Ki: 6.8μM) 및 β-amylase에 대한 억제 효과가 있습니다. 쿠세놀A는 피부 미백 및 노화를 위해 화장품이 표적으로 하는 효소의 잠재적 억제제로 확인됐다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 99217-63-7
Sample solution is provided at 25 µL, 10mM.
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Kushenol A is isolated from the root of Sophora flavescent, a non-competitive tyrosinase inhibitor with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively[1].Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase and beta-amylase[2].Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].
[1]. Kim JH, et al. Kushenol A and 8-prenylkaempferol, tyrosinase inhibitors, derived from Sophora flavescens. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. [2]. Kim JH, et al. Glycosidase inhibitory flavonoids from Sophora flavescens. Biol Pharm Bull. 2006 Feb;29(2):302-5.
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