MSDC-0602 (Synonyms: MSDC-0602) |
| رقم الكتالوجGC36658 |
MSDC-0602 (MSDC-0602) ، PPARγ ؛ - يتفاعل ثيازوليدينديون (TZD) مع ناقل بيروفات الميتوكوندريا (MPC) ويثبط نشاطه ولديه القدرة على دراسة مرض السكري من النوع 2 مع تقليل مخاطر الإصابة بـ PPARγ ؛ تأثيرات.
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Cas No.: 1133819-87-0
Sample solution is provided at 25 µL, 10mM.
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MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects[1][2].
[1]. Chen Z, et al. Resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. [2]. Vigueira PA, et al. The beneficial metabolic effects of sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017 Aug 1;102(8):985-999.
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