PI3Kα/mTOR-IN-1 |
| رقم الكتالوجGC36909 |
PI3Kα؛ / mTOR-IN-1 هو مثبط PI3Kα؛ / mTOR ثنائي فعال ، مع IC50 من 7 نانومتر لـ PI3Kα ؛ في فحص الخلية ، و Kis 10.6 نانومتر و 12.5 نانومتر لـ mTOR و PI3Kα ؛ في فحص الخلية الحرة ، على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1013098-90-2
Sample solution is provided at 25 µL, 10mM.
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PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively. PI3Kα|7 nM (IC50, Cell Assay)|PI3Kα|12.5 nM (Ki)|mTOR|10.6 nM (Ki)
PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties[1].
PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1].
[1]. Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5098-103.
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