QM385 |
| رقم الكتالوجGC37049 |
QM385 هو أحد مثبطات اختزال sepiapterin القوية (SPR) مع IC50 من 1.49 نانومتر ، والذي يمنع تكاثر الخلايا التائية والمناعة الذاتية بفاعلية نانوية مع توافر حيوي جيد عن طريق الفم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2296727-52-9
Sample solution is provided at 25 µL, 10mM.
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QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1]. IC50: 1.49 nM (Sepiapterin reductase)[1]
QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].
[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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