QM385 |
| Katalog-Nr.GC37049 |
QM385 ist ein potenter Sepiapterinreduktase (SPR)-Inhibitor mit einem IC50 von 1,49 nM, der die T-Zell-Proliferation und AutoimmunitÄt bei nanomolarer Potenz und mit guter oraler BioverfÜgbarkeit blockiert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2296727-52-9
Sample solution is provided at 25 µL, 10mM.
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QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1]. IC50: 1.49 nM (Sepiapterin reductase)[1]
QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].
[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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