Tigloylgomisin H |
| رقم الكتالوجGC37791 |
Tigloylgomisin H هو قشور معزول من ثمار S. chinensis ، ويمكن أن يحفز نشاط اختزال الكينون (QR) في خلايا سرطان الكبد Hepa1c1c7يعمل Tigloylgomisin H كمحفز أحادي الوظيفة ينظم على وجه التحديد إنزيم إزالة السموم من المرحلة الثانية NQO1 من خلال مسار العامل 2 المرتبط بـ NF-E2 (Nrf2) -ARE ، وبالتالي يمثل عاملًا محتملاً للوقاية من سرطان الكبد
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Cas No.: 66069-55-4
Sample solution is provided at 25 µL, 10mM.
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Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].
[1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.
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