Tigloylgomisin H |
| Catalog No.GC37791 |
La tigloylgomisine H est un lignane isolé des fruits de S. chinensis, peut induire une activité de quinone réductase (QR) dans les cellules d'hépatocarcinome de souris Hepa1c1c7. La tigloylgomisine H fonctionne comme un inducteur monofonctionnel qui régule spécifiquement À la hausse l'enzyme de détoxification de phase II NQO1 via la voie NF-E2-related factor 2 (Nrf2)-ARE, représente ainsi un agent potentiel de prévention du cancer du foie.
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Cas No.: 66069-55-4
Sample solution is provided at 25 µL, 10mM.
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Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].
[1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.
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