Tigloylgomisin H |
| Katalog-Nr.GC37791 |
Tigloylgomisin H ist ein aus den FrÜchten von S. chinensis isoliertes Lignan, das die AktivitÄt der Chinonreduktase (QR) in Hepa1c1c7-Maus-Hepatokarzinomzellen induzieren kann. Tigloylgomisin H fungiert als monofunktionaler Induktor, der das Phase-II-Entgiftungsenzym NQO1 Über den NF-E2-verwandten Faktor 2 (Nrf2)-ARE-Weg spezifisch hochreguliert und somit ein potenzielles Mittel zur Vorbeugung von Leberkrebs darstellt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66069-55-4
Sample solution is provided at 25 µL, 10mM.
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Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].
[1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.
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