TM6089 |
رقم الكتالوجGC37801 |
TM6089 هو مثبط فريد من نوعه لـ Prolyl Hydroxylase (PHD) الذي يحفز نشاط HIF بدون استخلاب الحديد ويحث على تكوين الأوعية الدموية ويمارس حماية الأعضاء ضد نقص التروية
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Cas No.: 863421-32-3
Sample solution is provided at 25 µL, 10mM.
TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector[1].
[1]. Nangaku M, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54.
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