Tubulysin E |
| رقم الكتالوجGC37839 |
Tubulysin E هو عبارة عن ببتيد شديد السمية للخلايا معزول عن الأنواع المتفطرة الجوفية Archangium geophyra و Angiococcus disciformisيعرض Tubulysin نشاطًا قويًا سامًا للخلايا في خلايا الثدييات ، بما في ذلك خطوط الخلايا المقاومة للأدوية المتعددة ، مع قيم IC50 في النطاق النانوي السفليTubulysin E هو نشاط سامة للخلايا يثبط بلمرة التوبولين ويؤدي إلى توقف دورة الخلية والاستماتة
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Cas No.: 309935-58-8
Sample solution is provided at 25 µL, 10mM.
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Tubulysin E is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin E is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
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