Dihydrolycorine |
رقم الكتالوجGC38171 |
ثنائي هيدروليكورين ، المعزول من Lycoris المشع Herb ، هو مثبط لتخليق البروتين في الخلايا حقيقية النواة عن طريق تثبيط خطوة تكوين العظام الببتيدية
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Cas No.: 6271-21-2
Sample solution is provided at 25 µL, 10mM.
Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities[1]. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step[2].
Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion[1].Dihydrolycorine inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively[3].
[1]. JIANG Shi-qin, et al. Therapeutic Effects of Dihydrolycorine on Focal Cerebral Ischemia-reperfusion Injury in Rats. 《Journal of Yunyang Medical College》 2009-05 [2]. Jimenez A, et al. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids. Biochim Biophys Acta. 1976 Mar 17;425(3):342-8. [3]. Chen BY, et al. [Hypotensive effect of dihydrolycorine]. Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.
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