NS13001 |
رقم الكتالوجGC38200 |
NS13001 عبارة عن مُعدِّل إيجابي خيفي قوي ، انتقائي ، نشط عن طريق الفم لقنوات SK (قنوات البوتاسيوم المنشط بالكالسيوم ذات التوصيل الصغير)
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Cas No.: 1063331-94-1
Sample solution is provided at 25 µL, 10mM.
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1].
[1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
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