NS13001 |
| Katalog-Nr.GC38200 |
NS13001 ist ein potenter, selektiver, oral aktiver allosterisch positiver Modulator von SK-KanÄlen (kalziumaktivierte KaliumkanÄle mit kleiner LeitfÄhigkeit).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1063331-94-1
Sample solution is provided at 25 µL, 10mM.
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NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1].
[1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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