Euscaphic acid |
| رقم الكتالوجGC38392 |
حمض Euscaphic ، مثبط DNA بوليميراز ، هو triterpene من جذر R. alceaefolius Poirيثبط Euscaphic بوليميريز DNA العجل α (pol α) وبوليميراز DNA الجرذ β (pol) بقيم IC 50 من 61 و 108 ميكرومترحمض اليوسكافيك يحث على موت الخلايا المبرمج
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Cas No.: 53155-25-2
Sample solution is provided at 25 µL, 10mM.
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Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].
Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].
[1]. Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200. [2]. Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098.
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