DPM-1001 |
| رقم الكتالوجGC38445 |
DPM-1001 هو مثبط قوي ، محدد ، فعال عن طريق الفم وغير تنافسي لبروتين فوسفاتيز التيروزين (PTP1B) مع IC 50 من 100 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1471172-27-6
Sample solution is provided at 25 µL, 10mM.
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DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].
[1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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