DPM-1001 |
| カタログ番号GC38445 |
DPM-1001 は、100 nM の IC50 を持つタンパク質チロシンホスファターゼ (PTP1B) の強力で特異的な経口活性の非競合的阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1471172-27-6
Sample solution is provided at 25 µL, 10mM.
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DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property[1].
[1]. Krishnan N, et al. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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