Estriol-d2 (Synonyms: E3-d2, 16αhydroxy17βEstradiol-d2, 1,3,5(10)Estratriene3,16α,17βtriol-d2)

Estriol-d2 is intended for use as an internal standard for the quantification of estriol by GC- or LC-MS. Estriol is a metabolite of estradiol and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.1 The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate and serves as a direct marker of fetal adrenal gland activity.2 Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.4

References
1. Peter, M., D•rr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Hormone Research 42, 278-281 (1994).
2. Goodwin, T.M. A role for estriol in human labor, term and preterm. American Journal of Obstetics and Gynecology 180, S208-S213 (1999).
3. Voss, H.F. Hormonal pathways of preterm birth. American Journal of Obstetics and Gynecology 180, S226-S231 (1999).
4. . Steroid levels in humans. (1999).