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Estriol-d2 (Synonyms: E3-d2, 16αhydroxy17βEstradiol-d2, 1,3,5(10)Estratriene3,16α,17βtriol-d2)

カタログ番号GC45450

Estriol-d2 は、Estriol とラベル付けされた重水素です。エストリオールは、エストロゲン受容体陰性乳癌細胞における G タンパク質共役エストロゲン受容体のアンタゴニストです。

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Estriol-d2 化学構造

Cas No.: 53866-32-3

サイズ 価格 在庫数 個数
500μg
$188.00
在庫あり
1mg
$325.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Estriol-d2 is intended for use as an internal standard for the quantification of estriol by GC- or LC-MS. Estriol is a metabolite of estradiol and a major estrogen produced in the later stages of pregnancy. In a longitudinal study in healthy pregnant women, total plasma estriol levels increased from <10 ng/ml at 8-10 weeks gestation to approximately 150 ng/ml at week 38.1 The majority of the estriol synthesized in the later stages of pregnancy originates from fetal dehydroepiandrosterone sulfate and serves as a direct marker of fetal adrenal gland activity.2 Saliva contains primarily unbound and unconjugated estriol and is commonly used for monitoring estriol levels.2,3 Plasma levels of estriol in males and non-pregnant females is less than 2 ng/ml.4

References
1. Peter, M., D•rr, H.G., and Sippell, W.G. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and at term. Hormone Research 42, 278-281 (1994).
2. Goodwin, T.M. A role for estriol in human labor, term and preterm. American Journal of Obstetics and Gynecology 180, S208-S213 (1999).
3. Voss, H.F. Hormonal pathways of preterm birth. American Journal of Obstetics and Gynecology 180, S226-S231 (1999).
4. . Steroid levels in humans. (1999).

Chemical Properties

Cas No. 53866-32-3 SDF
同義語 E3-d2, 16αhydroxy17βEstradiol-d2, 1,3,5(10)Estratriene3,16α,17βtriol-d2
Canonical SMILES OC1=C([2H])C=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])C[C@@H](O)[C@@H]4O)=C1[2H]
Formula C18H22D2O3 M.Wt 290.4
溶解度 DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4435 mL 17.2176 mL 34.4353 mL
5 mM 0.6887 mL 3.4435 mL 6.8871 mL
10 mM 0.3444 mL 1.7218 mL 3.4435 mL
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