Ginsenoside F1 (Synonyms: GF1, Panaxoside A Progenin) |
| رقم الكتالوجGN10032 |
Ginsenoside F1 is a secondary metabolite extracted from ginseng and is a desugared derivative of ginsenoside Rg1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 53963-43-2
Sample solution is provided at 25 µL, 10mM.
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Ginsenoside F1 is a secondary metabolite extracted from ginseng and is a desugared derivative of ginsenoside Rg1 [1]. Ginsenoside F1 promotes NK cell cytotoxic activity through an insulin-like growth factor-1-dependent mechanism [2]. Ginsenoside F1 is mainly used to treat cancer and inflammation [3].
In Human umbilical vein endothelial cells (HUVECs), Ginsenoside F1 (20, 40μM; 24h) promotes the proliferation, migration and invasion of HUVECs [4]. In HEK293 cells, Ginsenoside F1 (50, 100, 200µg/mL; 4h) significantly suppressed the proliferation of B16 melanoma up to 60% at 200µg/mL [5]. In HaCat cells, Ginsenoside F1 (1, 5, 10, 50μM; 24h) protects HaCat cells from UVB-induced apoptosis [6]. In SH-SY5Y cells, Ginsenoside F1 (2.5, 5, 10μM; 24h) Reduces Aβ1–42-induced cytotoxicity in neuronal cells [7].
In Alzheimer’s disease (AD) model mice, Ginsenoside F1 (20mg/kg; po; 8 weeks) improves memory function in APPswe/PSEN1dE9 (APP/PS1) double-transgenic AD model mice [8]. In high fat diet induced ApoE-/- atherosclerosis mice, Ginsenoside F1 (50mg/kg; ig; 8 weeks) improves endothelial cell inflammatory injury and prevents atherosclerosis in mice via A20-mediated inhibition of NF-kB signaling [9]. In ob/ob mice, administration of ginsenoside F1 (60mg/kg; ig; 5 weeks) augments thermogenesis to lower blood glucose and lipid [10].
References:
[1]. Meragelman TL, Renteria BS, Silva GL, et al. Modified secoiridoid from Acicarpha tribuloides and inhibition of nitric oxide production in LPS-activated macrophages. Phytochemistry. 2006 Jul 1; 67(14): 1534-1538.
[2]. Kwon HJ, Lee H, Choi GE, et al. Ginsenoside F1 promotes cytotoxic activity of NK cells via insulin-like growth factor-1-dependent mechanism. Frontiers in Immunology. 2018 Nov 28; 9: 2785.
[3]. Li J, Li F, Jin D. Ginsenosides are promising medicine for tumor and inflammation: A review. The American journal of Chinese medicine. 2023 Apr 17; 51(04): 883-908.
[4]. Zhang J, Liu M, Huang M, et al. Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway. Pharmacological Research. 2019 Jun 1; 144: 292-305.
[5]. Yoo DS, Rho HS, Lee YG, et al. Ginsenoside F1 modulates cellular responses of skin melanoma cells. Journal of Ginseng Research. 2011; 35(1): 86-91.
[6]. Lee EH, Cho SY, Kim SJ, et al. Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2. Journal of investigative dermatology. 2003 Sep 1; 121(3): 607-613.
[7]. Yun YJ, Park BH, Hou J, et al. Ginsenoside F1 protects the brain against amyloid beta-induced toxicity by regulating IDE and NEP. Life. 2022 Jan 1; 12(1): 58.
[8]. Han J, Oh JP, Yoo M, et al. Minor ginsenoside F1 improves memory in APP/PS1 mice. Molecular Brain. 2019 Dec; 12: 1-8.
[9]. Qin M, Luo Y, Lu S, et al. Ginsenoside F1 ameliorates endothelial cell inflammatory injury and prevents atherosclerosis in mice through A20-mediated suppression of NF-kB signaling. Frontiers in Pharmacology. 2017 Dec 22; 8: 953.
[10]. Meng Y, Li W, Hu C, et al. Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance. Food Science and Human Wellness. 2023 Nov 1; 12(6): 2061-2072.
| Cell experiment [1]: | |
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Cell lines |
Human umbilical vein endothelial cells (HUVECs) |
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Preparation Method |
The effect of Ginsenoside F1 on the proliferation of HUVECs was measured using the EdU cell proliferation assay. Briefly, HUVECs or HBMECs (3 × 103 cells/well) were seeded in 96-well plates and cultured overnight. Then, the cells were treated with Ginsenoside F1 (20 and 40μM) for 24h, according to the standard protocol of the EdU cell proliferation kit. |
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Reaction Conditions |
20, 40μM; 24h |
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Applications |
Ginsenoside F1 promotes the proliferation, migration and invasion of HUVECs. |
| Animal experiment [2]: | |
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Animal models |
Alzheimer’s disease (AD) model mice |
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Preparation Method |
To test the effect of Ginsenoside F1 on AD, Ginsenoside F1 was orally administrated via gelatin-based jelly at a dose level of 20mg/kg/day. For a 1-d dose of jelly, 0.6mg of Ginsenoside F1 was dissolved in 0.45mL of 20% Splenda solution. Ginsenoside F1 solution was further mixed with 1.35mL of 14% gelatin, 20% Splenda solution, and 0.15mL chocolate-flavoring in a 24-well plate. A piece of jelly (~ 1.9mg) was provided, and complete intake of jelly was confirmed daily. |
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Dosage form |
20mg/kg; po; 8 weeks |
|
Applications |
Ginsenoside F1 improves memory function in APPswe/PSEN1dE9 (APP/PS1) double-transgenic AD model mice. |
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References: |
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| Cas No. | 53963-43-2 | SDF | |
| المرادفات | GF1, Panaxoside A Progenin | ||
| Chemical Name | (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[(2R)-6-methyl-2-[(6R,10R,12S,13R,14R,17S)-3,6,12-trihydroxy-4,4,10,14,17-pentamethyl-2,3,5,6,7,8,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triol | ||
| Canonical SMILES | CC(=CCCC(C)(C1(CCC2(C1C(CC3C2CC(C4C3(CCC(C4(C)C)O)C)O)O)C)C)OC5C(C(C(C(O5)CO)O)O)O)C | ||
| Formula | C36H62O9 | M.Wt | 638.87 |
| الذوبان | ≥ 31.95mg/mL in DMSO with ultrasonic | Storage | Store at 2-8°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5653 mL | 7.8263 mL | 15.6526 mL |
| 5 mM | 313.1 μL | 1.5653 mL | 3.1305 mL |
| 10 mM | 156.5 μL | 782.6 μL | 1.5653 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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