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GNE 0723

رقم الكتالوجGC31270

GNE 0723 هو مُعدِّل خيفي إيجابي نفاذي للدماغ من NMDAR ، مع EC50 من 21 نانومتر لـ GluN2A ، 7.4 و 6.2 ميكرومتر لـ GluN2C و GluN2D ، على التوالي.

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GNE 0723 التركيب الكيميائي

Cas No.: 1883518-31-7

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

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