>>Signaling Pathways>> Neuroscience>> iGluR>>GNE 0723

GNE 0723

Catalog No.GC31270

GNE 0723은 NMDAR의 뇌 투과성 양성 알로스테릭 조절제로서 GluN2A의 경우 EC50이 21nM, GluN2C 및 GluN2D의 경우 각각 7.4 및 6.2μM입니다.

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GNE 0723 Chemical Structure

Cas No.: 1883518-31-7

Size 가격 재고
10mM (in 1mL DMSO) Please Inquire Please Inquire
1mg Please Inquire Please Inquire
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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively[1].

[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

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