GS-441524 |
| رقم الكتالوجGC46152 |
يُظهر GS-441524 ، المستقلب السائد لـ Remdesivir والمتفوق على Remdesivir ضد Covid-19 ، فعالية مماثلة في النماذج القائمة على الخلايا لخلايا الرئة البشرية الأولية والقطط المصابة بفيروس كورونا
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1191237-69-0
Sample solution is provided at 25 µL, 10mM.
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GS-441524 is an antiviral nucleoside analog and the active metabolite of remdesivir. [1] GS-441524 is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 μM, respectively). It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 μM, respectively).[2] Reference: [1]. Agostini, M.L., Andres, E.L., Sims, A.C., et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. mBio 9(2), e00221-00218 (2018). [2]. Cho, A., Saunders, O.L., Butler, T., et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg. Med. Chem. 22(8), 2705-2707 (2012).
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