NSC 636819 |
| رقم الكتالوجGC50136 |
NSC 636819 هو مثبط تنافسي وانتقائي لـ KDM4A / KDM4B. KDM4A / KDM4B عوامل تقدم محتملة لسرطان البروستاتا. NSC 636819 لديه القدرة على البحث عن أمراض السرطان ، وخاصة سرطان البروستاتا.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1618672-71-1
Sample solution is provided at 25 µL, 10mM.
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KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.
Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID:24971742
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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