HC Toxin (Synonyms: Toxin I (Helminthosporium carbonum)) |
| رقم الكتالوجGC43806 |
HC Toxin ، رباعي ببتيد دوري ، هو مثبط قوي لـ HDAC مع IC 50 من 30 نانومتر. يحفز HC Toxin موت الخلايا المبرمج للخلايا السرطانية وله تأثيرات مضادة للسرطان.
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Cas No.: 83209-65-8
Sample solution is provided at 25 µL, 10mM.
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HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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