HDACs/mTOR Inhibitor 1 |
| رقم الكتالوجGC65460 |
HDACs / mTOR Inhibitor 1 هو ثنائي هيستون Deacetylases (HDACs) وهدف الثدييات لمثبط الهدف Rapamycin (mTOR) لعلاج الأورام الخبيثة الدموية ، مع IC50s 0.19 نانومتر ، 1.8 نانومتر ، 1.2 نانومتر و> 500 نانومتر لـ HDAC1 ، HDAC6 ، mTOR و PI3Kα ، على التوالييحفز مثبط HDACs / mTOR 1 إيقاف دورة الخلية في طور G0 / G1 ويحث على موت الخلايا المبرمج للخلايا السرطانية مع سمية منخفضة في الجسم الحي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2271413-06-8
Sample solution is provided at 25 µL, 10mM.
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HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].
[1]. Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.
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