HIF-2α-IN-3 |
| رقم الكتالوجGC62418 |
HIF-2α ؛ -IN-3 ، مثبط خيفي لعامل نقص الأكسجة المحرض -2α ؛ (HIF-2α ؛) ، يعرض IC50 بقيمة 0.4 μ ؛ M و KD من 1.1 μ ؛ M. عامل مضاد للسرطان.
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Cas No.: 313964-19-1
Sample solution is provided at 25 µL, 10mM.
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HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1].
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].
[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.
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